1/28/2024 0 Comments System shock 2 wiki healing glandKeratinocytes are the major cell population of epidermis important for maintaining a barrier formation during homeostasis as well as restoring it after the injury. The epithelialization process is impaired in all types of chronic wounds.įuture Directions: A comprehensive understanding of the epithelialization process will ultimately lead to the development of novel therapeutic approaches to promote wound closure. A wound cannot be considered healed in the absence of re-epithelialization. Novel mechanisms of gene expression regulation important for re-epithelialization, including microRNAs and histone modifications, will also be discussed.Ĭritical Issues: Epithelialization is an essential component of wound healing used as a defining parameter of a successful wound closure. Recent Advances: Discoveries in epidermal stem cells, keratinocyte immune function, and the role of the epidermis as an independent neuroendocrine organ will be reviewed. ![]() This review will focus on the pivotal role of keratinocytes in epithelialization, including cellular processes and mechanisms of their regulation during re-epithelialization, and their cross talk with other cell types participating in wound healing. ![]() Significance: Keratinocytes, a major cellular component of the epidermis, are responsible for restoring the epidermis after injury through a process termed epithelialization.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |